GJA1 and neoplasm: Zibara et al. [39] found that functional Cx43 channels promote transendothelial migration during metastasis via tumor-endothelial communication, which can be blocked by gap junction inhibitors, potentially due to a variety of factors, such as differences in model systems, differences in tumor development stage, specificity of microenvironment, changes in subcellular localization of Cx43, and post-translational modifications.