PIK3CA and endometrial cancer: In Ishikawa and HEC-1B endometrial cancer cells, SNORD60 guides FBL to methylate PIK3CA mRNA, enhancing its translation, activating the PI3K/AKT/mTOR pathway, and promoting tumor growth and survival, thereby functioning as an oncomiR by modulating FBL activity beyond its canonical role in rRNA modification [39].