In lung adenocarcinoma, resistance to doxorubicin and cisplatin is associated with increased expression of ATP-binding cassette (ABC) transporters—including ABCB1, ABCC1 and ABCG2, encoding p-glycoprotein, MRP1, and BCRP proteins, respectively, ref. [18]—as well as elevated levels of sirtuin 1 (SIRT1) protein [19]. The gene discussed is SIRT1; the disease is lung adenocarcinoma.