On one hand, malnutrition and inflammation may contribute to psychological vulnerability through metabolic stress, cytokine-mediated neurobehavioral pathways, and reduced physiological reserve, as supported by longitudinal and interventional studies showing that hypoalbuminemia, elevated CRP, and composite malnutrition–inflammation scores predict adverse clinical and functional outcomes in hemodialysis patients [45,46]. This evidence concerns the gene CRP and malnutrition.