On one hand, malnutrition and inflammation may contribute to psychological vulnerability through metabolic stress, cytokine-mediated neurobehavioral pathways, and reduced physiological reserve, as supported by longitudinal and interventional studies showing that hypoalbuminemia, elevated CRP, and composite malnutrition–inflammation scores predict adverse clinical and functional outcomes in hemodialysis patients [45,46]. The gene discussed is CRP; the disease is nutritional deficiency disease.