Studies have found that Tripartite Motif-Containing 46 (TRIM46) mediates the ubiquitination of PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) via its PH domain, thereby activating the AKT/HK2 signaling pathway and ultimately promoting chemoresistance in lung cancer cells [13]. Here, TRIM46 is linked to lung cancer.