TRIM14 has been shown to interact with Glutamine: Fructose-6-Phosphate Amidotransferase 1 (GFAT1), the rate-limiting enzyme in the hexosamine biosynthesis pathway (HBP), promoting its ubiquitination-mediated degradation, thereby suppressing HBP flux and exerting tumor-suppressive effects [39]. The gene discussed is GFPT1; the disease is neoplasm.