HOTAIR and digestive system cancer: However, rs7958904 may alter HOTAIR’s secondary structure (in silico CRC-related study [52]), H19 rs2839698 is linked to higher risk in digestive system cancers [68], and PTCSC3 rs944289 reduces promoter activity and PTCSC3 expression in thyroid carcinoma [60] (GWAS Catalog: GCST000335).