PTCSC3 and thyroid gland carcinoma: Conversely, while papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) is well established as a tumor-suppressive lncRNA, partly through the inhibition of oncogenic signaling pathways, it is consistently downregulated in thyroid carcinoma and has been reported in several other digestive malignancies [33,34,35,36,37].