This concludes for the endocrine MEN1 disorders no generally recognized genotype–phenotype correlation for parathyroid-hyperplasia resulting hyperparathyroidism, pituitary adenomas, and functional hypersecretory pituitary syndromes, adrenal adenomas/disorders, pNETs, and functional syndromes; or the development of carcinoids (gastric, thymic, lung) as well as for the development of nonendocrine tumors/abnormalities (skin-[angiofibromas, collagenomas], CNS tumors [meningiomas, schwannomas, ependymomas, smooth muscle tumors, breast cancer]) [290,317,328,331,400,426]. This evidence concerns the gene MEN1 and smooth muscle tumor.