Numerous more recent studies report that MEN1 patients also develop smooth muscle tumors (leiomyomas, leiomyosarcomas), CNS tumors (meningiomas, schwannomas, ependymomas), skin tumors (angiofibromas > collagenomas > lipomas > melanoma), as well as breast, urological, and other tumors [50,290,326,328,329,330,331,332,333]. This evidence concerns the gene MEN1 and central nervous system neoplasm.