Further, in dopaminergic neurons differentiated from iPSCs from PD patients with a mutation in the PARK7 gene as well as in dopaminergic neurons differentiated from iPSCs from healthy controls with a CRISPR-CAS9 mediated knock-out of PARK7, NM production was observed resulting from elevated dopamine oxidation after an extended time period in culture [74]. The gene discussed is PARK7; the disease is Parkinson disease.