From a dermatologic standpoint, anti-VEGFR multikinase inhibitors are mainly associated with hand–foot skin reaction (HFSR), xerosis/fissuring and onychopathies, whereas selective RET and NTRK inhibitors tend to induce hypersensitivity-type rash, pruritus and pigmentary alterations, generally of milder grade but often prolonged over time [20,21]. The gene discussed is RET; the disease is Dry skin.