Husson et al. [140] tested some of the episignatures from a past version of the EpiSign classifier [26], and other independent studies conducted in the same disease [49,61,126,133,141]: ATRX, ASD18 (CHD8), Cornelia de Lange syndrome (NIPLB), CHARGE (CHD7), Kabuki (KMT2D), Claes–Jensen (KDM5C), Rubinstein-Taybi (CREBBP), Sotos (NSD1), Tatton-Brown–Rahman (DNMT3A), and Wiedemann–Steiner (KMT2A). This evidence concerns the gene NSD1 and Cornelia de Lange syndrome.