The immune infiltrate in diffuse glioma is highly heterogeneous, and the immune landscape of the glioma tumor microenvironment is predominantly composed of myeloid cells, with lymphocytes being comparatively sparse, including macrophages, microglia, myeloid-derived suppressor cells, lymphocytes (such as CD8+ cytotoxic T cells, CD4+ regulatory T cells, and B cells), natural killer (NK) cells, and neutrophils. The gene discussed is CD8A; the disease is central nervous system cancer.