IDH1 and glioma: Notably, in a study utilizing 31P/1H-MRS, Wenger et al. reported a marked disparity in in vivo lactate concentrations between these subgroups, with mean levels of 5.4 ± 4.1 mmol/L in IDH-mut gliomas versus 11.7 ± 4.3 mmol/L in IDH-wt counterparts [17].