Both KLK7 and KLK14 are known for taking part in the desquamation of the stratum corneum by digestion of corneodesmosomes and being involved in the pathogenesis of skin diseases such as Netherton syndrome, atopic dermatitis, psoriasis and melanoma [23,24,25,26,27] Regarding KLK7, its expression in murine pancreatic β-cells is also well established [18]. Here, KLK7 is linked to melanoma.