For neuroinvasion—a hallmark of PDAC—scRNA-seq combined with spatial transcriptomics mapping identified two highly invasive cancer cell subpopulations: D09_Ductal-CEACAM6 (basal-like) and D04_Ductal-GABRP (neurotransmitter-responsive), along with TGFBI+ Schwann cell subpopulations induced by TGFβ1. The gene discussed is TGFBI; the disease is cancer.