The development of new approaches to modulate the immune response using promising synthetic compounds opens up the possibility of targeted cytokine balance restoration of cytokine balance and Tregs functions This study investigated the effects of the newly synthesized complex of 1-(2-Ethoxypropyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate with β-Cyclodextrin (MXF-22), on the populations of CD4+, CD4+CD25+ and CD4+FoxP3+ T cells in an oleic acid-induced acute lung injury rat model. Here, CD4 is linked to acute lung injury.