MYC and familial pancreatic carcinoma: Additionally, regarding the link between the SUMOylation pathway and the MYC oncogene, researchers found that the small-molecule inhibitors of SUMO ligase (SAE)—namely, ML-792 and ML-93—can mediate G2/M phase cell cycle arrest and induce apoptosis, thereby effectively inhibiting pancreatic cancer growth as validated in both the tumour organoid model and the subcutaneous model [184].