SDCBP inhibits the CK1δ/ε-mediated phosphorylation of YAP at Ser384/Ser387 by binding to YAP1, thereby blocking β-TrCP-dependent ubiquitin-mediated degradation of YAP1 and suppressing pancreatic cancer proliferation and metastasis [99]. This evidence concerns the gene BTRC and familial pancreatic carcinoma.