Firstly, the natural flavonoid fisetin exhibits a dual mechanism of action: on one hand, it inhibits pancreatic cancer stem cell properties and enhances gemcitabine sensitivity, which has been validated in both the KPC model and the subcutaneous model, by increasing acetylation levels at the Lys33 site of CDK1, thereby suppressing its phosphorylation [167]; concurrently, it promotes acetylation at sites Lys68 and Lys122 of SOD2 by suppressing the expression of the deacetylase SIRT2, thereby inhibiting pancreatic cancer cell proliferation and inducing apoptosis [168]. Here, SOD2 is linked to familial pancreatic carcinoma.