Several DUBs converge on stabilisation of transcriptional regulators: USP28 stabilises FOXM1 to enhance Wnt/β-catenin signalling and suppress apoptosis [114]; USP22 deubiquitinates and stabilises PTEN, upregulating p21 and promoting tumour growth [115]; and PSMD7 stabilises SOX2, thereby activating the Notch1 pathway [116]. The gene discussed is SOX2; the disease is neoplasm.