In 2023, Dai et al. [27] employed CERES-based algorithms to analyze DepMap CRISPR loss-of-function data regarding HNSCC, uncovering 68 essential genes associated with overall survival and then refining these to 8 independent prognosticators via LASSO (PSMD2, TXNRD1, SLC7A5, CDK6, AP2M1, EGFR, AURKA, and PLK1). Here, PLK1 is linked to head and neck squamous cell carcinoma.