TGFB1 and Granuloma: Pathways related to Th17 were also enriched, including “positive regulation of Th17 type immune response,” “positive regulation of IL-17 production,” “IL-17 signaling pathway,” and “Th17 cell differentiation.” Th17 cells, which differentiate from CD4+ T cells under IL-6 and transforming growth factor beta (TGF-β) stimulation, are implicated in granuloma formation [21].