RIGI and breast cancer: For instance, the combination of DNA methyltransferase (DNMT) and histone deacetylase (HDAC) inhibitors with anti-programmed death-ligand 1 (anti-PD-L1) antibodies has been shown to induce viral mimicry in breast cancer cells, leading to the activation of the retinoic acid-inducible gene I (RIG-I)–mitochondrial antiviral-signaling protein (MAVS) pathway and the production of type I interferons [12].