It demonstrates antiproliferative activity against Breast Cancer Resistance Protein-expressing MDA-MB-231 cells (MB-231/BCRP), doxorubicin-resistant leukemia cells (CEM/ADR5000), and glioblastoma cells expressing EGFRvIII (U87MG.ΔEGFR) [34]. Here, ABCG2 is linked to leukemia.