ATXN2 and open-angle glaucoma: Recently CRISPR/Cas9-mediated knockdown studies in zebrafish showed that the loss of Atxn2 led to a reduction in eye size, a decrease in retinal ganglion cells, an increase in intraocular pressure, and impaired visual function, suggesting a possible new role for ATXN2 in the pathogenesis of primary open-angle glaucoma [47].