IL6 and acute kidney injury: Clinically, markedly elevated inflammatory biomarkers should flag a high-risk AKI phenotype, warranting closer renal monitoring, meticulous volume management, avoidance of nephrotoxic drugs, and early supportive measures; anti-inflammatory strategies (e.g., corticosteroids, IL-6 blockade, extracorporeal hemoadsorption) may confer indirect kidney protection, although data remain limited.