To allow epithelial cells undergoing EMT to detach from their neighboring cells in the primary tumor, the EMT transcription factors (EMT-TFs) (e.g., Snail/SNAI1, Slug/SNAI2, Zeb1 and Twist1) suppress the expression of adhesion molecules (e.g., E-cadherin, claudins) and promote the expression of genes such as vimentin and N-cadherin [10,11]. This evidence concerns the gene SNAI2 and neoplasm.