Although significant progress has been made in NSUN family gene research, the following aspects should be explored further: the mechanism research is imperfect, the role of m5C modification in carcinogenesis is not fully understood, the NSUN2 gene significantly influences cancer research most studies have indicated that NSUN2 promotes the progression of various cancers, and there is relatively little research on other genes in the family. This evidence concerns the gene NSUN2 and cancer.