Another study applied disease pathways analysis and found that the proteins Thbs1 (or TSP-1), KNG1, Histidine-rich glycoprotein (HRG), and F9, F10, and F12 were upregulated in HPV+ variant P16-induced oropharyngeal tumours compared to non-P16 variant HPV+ tumours [25]. The gene discussed is HRG; the disease is neoplasm of oropharynx.