The hyperactivation of PI3K/Akt/mTOR resulted in decreased autophagy in the aluminum-induced AD rats’ brains, and the findings showed the restoration of this axis in MSC-derived exosomes together with the mTOR inhibitor group, as can be seen through increased autophagy activity along with decreased APP cleavage, increased proteolytic degradation of aβ and improved memory performance. This evidence concerns the gene MTOR and Alzheimer disease.