BDNF and Alzheimer disease: A study by Gaber et al. [121] also focused on the Akt/GSK-3β pathway, where it showed that IV of bone marrow-derived MSCs (BMSCs) into Aβ25-35-induced AD rat dams during pregnancy was able to reverse the downregulation of BDNF and upregulation of GSK-3β levels at postnatal age, which contribute to the mitigation of AD.