CD274 and neoplasm: Complementarily, He et al. showed that M2-macrophage exosomes package HOXC13-AS, which lifts PD-L1 expression via the miR-485-5p/IGF2BP2 axis and fuels immune escape; CRISPR ablation of HOXC13-AS cut tumour volume by 52% in syngeneic mice [31].