Engagement of Fas by FasL recruits the Fas-associated death domain (FADD), activates caspase-8 and the downstream caspase cascade, and ultimately drives apoptosis; TNF-related apoptosis-inducing ligand (TRAIL) uses similar receptor–ligand interactions to promote lymphocyte death in sepsis [55,56,57,58]. This evidence concerns the gene FASLG and Sepsis.