EFEMP2 and cancer: Moreover, as with MMP-10, work by Li et al. [29] described studies on a new therapeutic target (EFEMP2) in CC on highly invasive cell lines (Ca Ski), where knockdown of the proposed therapeutic target gene was simultaneously associated with a decrease in MMP-3 expression, which may also indirectly confirm the theory that high expression and concentrations of MMP-3 may be associated with cancer progression.