This study evaluated a pragmatic composite—TRIAD-TB—integrating physiology (SpO2, respiratory rate), inflammation (systemic immune-inflammation index [SII], C-reactive protein [CRP]), and nutrition (BMI, albumin), augmented by 72 h changes in CRP and albumin, to predict 30-day mortality and hospital length of stay (LOS). The gene discussed is CRP; the disease is tuberculosis.