Clinically, this supports a two-timepoint strategy: (i) admission triage with the mini-TRIAD to trigger closer monitoring, early ICU outreach, and nutrition consults for high-risk patients; and (ii) a scheduled day-3 “re-stratification” using the full TRIAD-TB, incorporating CRP ratio and albumin change, to detect non-responders and prompt escalation (repeat imaging, search for complications, expedited DST/MDR evaluation, adherence/toxicity checks) and proactive discharge planning. This evidence concerns the gene CRP and tuberculosis.