PTN and cancer: In contrast, upregulated genes in sensitive cell lines were enriched in pathways related to EMT process (CDH2, SNAI2, ZEB2, IL6) [39,40], ECM remodeling (MMP2, LOX, COL4A1, COL8A1) [10], cancer stemness (PTGS2/COX-2) [41,42], angiogenesis and cell migration (FGF2, EDIL3, PTN) [43,44,45], and drug resistance and metastasis (ETS1, AXL, ADAMTS12) [46,47,48].