Conditional deletion of the FASN gene in OLCs shows that, even without impairing OPCs proliferation and differentiation, loss of FASN severely disrupts myelin formation and growth, leading to thinner myelin and reduced axonal stability; in an adult lysophosphatidylcholine-induced demyelination model, adult OPCs lacking FASN fail to remyelinate effectively [50]. Here, FASN is linked to Peripheral demyelination.