In a cisplatin-treated AKI mouse model, USP7 knockout exacerbates Bcl-2 degradation and tubular apoptosis, while USP7 overexpression or use of a USP7 agonist (e.g., HBX 41108) significantly increases Bcl-2 levels, alleviates kidney injury, and improves renal function [79,80]. Here, BCL2 is linked to acute kidney injury.