Deubiquitination of NLRP3 by BRCC3 (BRCA1/BRCA2-containing complex subunit 3) is required for inflammasome activation, while K48-linked ubiquitination by FBXL2 (F-box and leucine-rich repeat protein 2) promotes its cisplatin-induced AKI degradation, increased NLRP3 inflammasome activation correlates with decreased FBXL2 expression, suggesting that dysregulated ubiquitination contributes to excessive inflammasome activity, Jefferies CA [71] research shows. Here, FBXL2 is linked to acute kidney injury.