In a cisplatin-treated AKI mouse model, USP7 knockout exacerbates Bcl-2 degradation and tubular apoptosis, while USP7 overexpression or use of a USP7 agonist (e.g., HBX 41108) significantly increases Bcl-2 levels, alleviates kidney injury, and improves renal function [79,80]. The gene discussed is USP7; the disease is acute kidney injury.