Non-response odds were higher with CAUTI (aOR 1.9, 95% CI 1.1–3.2), longer time-to-effective therapy per 6 h (aOR 1.5, 1.2–2.0), baseline CRP per 20 mg/L (aOR 1.3, 1.0–1.7), and diabetes (aOR 1.8, 1.0–3.3). Here, CRP is linked to diabetes mellitus.