MAPT and Alzheimer disease: Macroscopically, the neuronal and synaptic loss in AD is marked by cerebral atrophy [26,47,48], while microscopically, it is defined by abnormal protein aggregation, such as Aβ-peptide forming senile plaques (SPs) and phosphorylated tau (p-tau) protein creating neurofibrillary tangles (NFTs) and neuropil threads [49,50,51,52].