It is demonstrated that the reduced expression of IL-10 is coupled with an increase of STAT-3 and a reduction of SOCS3 mRNA, indicating an essential modulation of the immune response, with attenuation of anti-inflammatory and an increase of proinflammatory mediators. This modulation may be related to the increased prevalence and severity of periodontitis in individuals with DS. Here, IL10 is linked to Dravet syndrome.