The cathepsin C, is a lysosomal cysteine protease that plays a key role in the activation of serine proteases in cytotoxic T cells, natural killer cells, mast cells, and neutrophils, crucial significance in immune and inflammatory defenses, the deficiency leads to impaired activation of protease three and reduced levels of the cathelicidin LL-37 peptide, thereby weakening the host’s capacity to eliminate periodontal bacteria, resulting in an oral environment highly permissive to bacterial colonization and rapid progression of periodontitis [2,14,26,28]. Here, CTSC is linked to periodontitis.