TIMP2 and acute kidney injury: Biomarkers of sepsis-associated organ dysfunction, including those for acute kidney injury (AKI), such as urinary tissue inhibitor of metalloproteinases-2 (TIMP-2) combined with insulin-like growth factor-binding protein 7 (IGFBP7) [7], as well as markers of immunosuppression, such as monocyte human leukocyte antigen–DR (mHLA-DR) [8], have also been investigated.