GH1 and Central hypothyroidism: The mother had a history of thyroid disease; however, no biochemical data (TSH, FT4, thyroid autoantibodies) were available to determine whether this indicated primary or central hypothyroidism; the patient’s older sister had been treated with growth hormone (GH) for growth hormone deficiency (GHD) from the ages of 10 to 15 years (Table 1).