Although the number of reported cases with CHD is small and these four cases represent three different biological mechanisms: outflow tract patterning (the BAV and LVOTO cases), pulmonary venous incorporation (our case), cardiomyocyte structural integrity (the DCM case), both clinical observations and animal model data suggest a possible role for NCKAP1 in cardiac development. Here, NCKAP1 is linked to coronary artery disorder.