According to the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), diagnosis in both breastfed and formula-fed infants should be based on a short elimination diet followed by a mandatory oral food challenge (OFC), except in cases presenting with severe allergic symptoms, such as anaphylaxis or markedly elevated CMP specific IgE levels [5]. Here, IGHE is linked to anaphylaxis.