In contrast, IgE-mediated CMPA presented predominantly with acute allergic symptoms (e.g., anaphylaxis: 92.6%, urticaria: 88.5%, angioedema: 87.7%, wheezing and asthma: 74.0%, and oral allergy syndrome: 71.0%; Supplementary Table S4). The gene discussed is IGHE; the disease is angioedema.