Similarly, HLA-DR protein expression in CD3+CD4+ Th cells (Figure 2B and Figure 3B) was increased in both the COPD-only group (2551 ± 956 MFI, adjusted p = 0.018) and the ACO group (2416 ± 914 MFI, adjusted p = 0.016) compared to the HS group (1836 ± 531 MFI). The gene discussed is CD4; the disease is chronic obstructive pulmonary disease.