Other phosphorylation sites include serine 114 (S114 in humans, S115 in mice) by casein kinase 2 (CK2) [104], which enhances interaction with peptidyl-prolyl isomerase NIMA 1 (PIN1) and blocks MATα1 mitochondrial targeting; and serine 180 (S180 in humans, S181 in mice) and threonine 202 (T202 in humans, T203 in mice) by AKT, which promote interaction with 14-3-3ζ and prevent MATα1 nuclear targeting in HCC [122]. The gene discussed is MAT1A; the disease is hepatocellular carcinoma.