Some binding partners include PIN1 [104] and 14-3-3ζ [122], described above, as well as p53 and DNA damage-regulated gene 1 (PDRG1) [107]; the latter interacts with MATα1 in the nucleus, resulting in decreased MAT activity and DNA hypomethylation in hepatoma cells. This evidence concerns the gene MAT1A and hepatocellular carcinoma.