Transcriptomic profiling reveals that male mice exposed to chronic stress upregulate vascular interaction genes such as fibroblast growth factor 2 (FGF2), angiotensinogen (AGT), angiopoietin-1 (ANGPT1), and AQP4 in the PFC, while females downregulate the same transcripts, suggesting sex-specific pathways of glial vulnerability that may contribute to the higher prevalence of depression in women [148]. The gene discussed is AQP4; the disease is major depressive disorder.