Beyond vascular effects, MitoQ has been shown to preserve mitochondrial integrity in tubular cells under hyperglycemia by enhancing mitophagy via the nuclear factor erythroid 2-related factor 2 (Nrf2)/PINK1 pathway, which Nrf2 directly controls PINK1 transcription under oxidative stress leading to PINK1 accumulation on damaged mitochondria, recruitment of Parkin, ubiquitination of outer membrane proteins, and selective autophagic clearance of dysfunctional mitochondria [83]. Here, NFE2L2 is linked to Hyperglycemia.