Similarly, for the down-regulated DEGs, they could be enriched into 208 pathways, especially the disease and immune response pathways (like Arrhythmogenic right ventricular cardiomyopathy, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, TNF signaling pathway) (Figure S5b), the functional genes included map2k1, myc, mmp9, wnt7, and socs3. The gene discussed is SOCS3; the disease is hypertrophic cardiomyopathy.