In murine models of T2DM, HBOT has also been shown to increase GLUT4 translocation and AMPK activation in skeletal muscle, as well as to enhance fatty acid oxidation and the expression of uncoupling protein 1 (UCP1) in adipocytes, thereby promoting browning of white adipose tissue (WAT) and improving overall energy metabolism [23]. The gene discussed is SLC2A4; the disease is type 2 diabetes mellitus.