SOD1 and ulcerative colitis: Saffron was found to restore the activities of key antioxidant enzymes, SOD and CAT, increase GSH levels, enhance GPx and GST activities, and significantly reduce malondialdehyde (MDA) levels [50].in another clinical study, 8 weeks of saffron supplementation in ulcerative colitis (UC) patients increased Total antioxidant capacity, SOD and GPx, while MDA decreased [51].