The inhibitory effects of four extracts from cornelian cherry fruits were evaluated against α-glucosidase, α-amylase, pancreatic lipase, acetylcholinesterase, and tyrosinase using diverse in vitro methods, aiming to elucidate their potential antidiabetic, anti-obesity, neuroprotective, and dermatological benefits. The gene discussed is ACHE; the disease is obesity due to melanocortin 4 receptor deficiency.