KEAP1 and lung cancer: To investigate the regulatory effect of KEAP1-KO cancer cells on macrophage polarization in vitro, we used RNA sequencing analysis of primary murine bone marrow-derived macrophages (BMDM) treated with LL2 lung cancer-conditioned media with or without CDDO-Me as shown in Figure 1A. LL2 cells are murine lung carcinoma cells derived from C57BL/6 mice and recapitulate features of human lung adenocarcinoma [48].