Furthermore, pathways differentially regulated in the KEAP1 KO and WT CM/CDDO-Me-treated groups align with an anti-tumor macrophage phenotype, evident by the increased interferon gamma (NES: 2.74–2.88, p < 1.00 × 10−9), interferon alpha (NES: 2.49–2.59, p < 1.00 × 10−9), and inflammatory responses (NES: 1.93–2.09, p = 2.00 × 10−6–1.99 × 10−9) (Figure 2B, Table S6). This evidence concerns the gene KEAP1 and neoplasm.