Single‐cell proteomic studies in mice with obesity, a state marked by increased pro‐inflammatory SC abundance especially in epididymal fat depots, indicated that within the senescent preadipocyte population (marked by p16+, p21Cip1+, γH2AX+), a cluster of cells highly expressing pro‐inflammatory/proapoptotic factors was more effectively eliminated by senolytics than other cell populations. Here, CDKN2A is linked to obesity disorder.