KEGG enrichment analysis revealed that non-tumor-specific boundary genes were associated with TGF-β signaling and PRC2 functions, whereas HB-specific boundary genes were involved in metabolic reprogramming pathways, including retinol metabolism, drug metabolism, and peroxisome-related pathways associated with lipid metabolism and ROS homeostasis (Fig. 1G). The gene discussed is TGFB1; the disease is neoplasm.