SOX2 and head and neck squamous cell carcinoma: For instance, KLF7 binds to the IGF2BP2-SE to drive IGF2BP2 overexpression and promote tumor progression in head and neck squamous cell carcinoma (HNSCC) [19], while TP63 and SOX2 co-activate SEs and the promoter of CCAT1 to drive tumorigenesis in squamous cell carcinomas (SCCs) [20].