TCF4 and hepatocellular carcinoma: For example, transcription factor 4 (TCF4) binds to the AJUBA SEs and promoter to promote epithelial-mesenchymal transition (EMT) and metastasis in hepatocellular carcinoma (HCC) [48], while MYCN invades and binds to enhancers to amplify tumor-specific transcriptional outputs in neuroblastoma [49].